Fertility and sterility · 1998
Acute infusion of naloxone, an opioid receptor antagonist, does not modify serum leptin concentrations in amenorrheic and healthy women.
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Genazzani A D, Menozzi R, Del Rio G, Luisi S, Petraglia F, Genazzani A R
Аннотация
OBJECTIVE: To determine whether the opioidergic system is involved in the modulation of leptin secretion in healthy and amenorrheic subjects.
DESIGN: Prospective study.
SETTING: Department of Obstetrics and Gynecology, University of Modena, Modena, Italy.
PATIENT(S): Healthy subjects (n = 8) and patients with hypothalamic amenorrhea (n = 17) or hyperandrogenism (n = 7) and low body mass index (BMI).
INTERVENTION(S): Acute infusion of naloxone (4-mg bolus) and blood sampling 15 minutes before infusion; at time of infusion; and 15, 30, 45, 60, 75, 90, and 120 minutes after infusion.
MAIN OUTCOME MEASURE(S): Plasma leptin, LH, FSH, E2, and cortisol concentrations.
RESULT(S): Plasma leptin concentrations were lower (P <.01) in both hypothalamic and hyperandrogenic amenorrheic subjects than in healthy controls. In all groups of subjects, no significant changes in leptin levels were observed after infusion of naloxone. A significant correlation was found between leptin concentrations and BMI when all subjects were considered together (P <.05) but was not found in the single groups.
CONCLUSION(S): The present data do not support the hypothesis that opioidergic receptors are involved acutely in the modulation of leptin release in healthy and amenorrheic women.
DESIGN: Prospective study.
SETTING: Department of Obstetrics and Gynecology, University of Modena, Modena, Italy.
PATIENT(S): Healthy subjects (n = 8) and patients with hypothalamic amenorrhea (n = 17) or hyperandrogenism (n = 7) and low body mass index (BMI).
INTERVENTION(S): Acute infusion of naloxone (4-mg bolus) and blood sampling 15 minutes before infusion; at time of infusion; and 15, 30, 45, 60, 75, 90, and 120 minutes after infusion.
MAIN OUTCOME MEASURE(S): Plasma leptin, LH, FSH, E2, and cortisol concentrations.
RESULT(S): Plasma leptin concentrations were lower (P <.01) in both hypothalamic and hyperandrogenic amenorrheic subjects than in healthy controls. In all groups of subjects, no significant changes in leptin levels were observed after infusion of naloxone. A significant correlation was found between leptin concentrations and BMI when all subjects were considered together (P <.05) but was not found in the single groups.
CONCLUSION(S): The present data do not support the hypothesis that opioidergic receptors are involved acutely in the modulation of leptin release in healthy and amenorrheic women.