Immunogenicity of the Stabilized Env Trimer HIV-1 CRF63_02A6 Produced in Protein and DNA Vaccine Formats.

Stabilized trimers of the HIV-1 Env surface glycoprotein are considered as one of the main directions in the design of an HIV-1 vaccine, both individually and in prime-boost immunization strategies. The article presents the results of a study of the immunogenicity of the Env trimer of the recombinant HIV-1 CRF63_02A6 in the form of a recombinant protein and a DNA vaccine, as well as in the prime-boost immunization scheme. The Env trimer in the form of a protein and a DNA vaccine induced the formation of specific antibodies with virus-neutralizing activity against HIV-1 Env-pseudoviruses.