Related factors of bloodstream infections associated with urinary tract infections and pathogenetic characteristics analysis.

OBJECTIVES

To explore correlations between biomarker indices and urosepsis severity, and investigate the prevalence of drug-resistant Escherichia coli in a patient population at the General Hospital of Ningxia Medical University in the Ningxia region of China.

METHODS

Patients with urinary tract infection-associated sepsis were categorized into three groups: a septic non-shock group (NSSPU), a septic shock group (USG), and a control group with non-sepsis cases of simple urinary tract infections (CG). The study analyzed various biomarkers, including the percentage of neutrophils (N%), neutrophil-to-lymphocyte ratio (NLR), and lactate (La), to assess their predictive value for urogenital sepsis severity.

RESULTS

The Kruskal-Wallis test showed significant differences in all measured biomarkers between the groups. ROC curve analysis identified N%, NLR, total protein (TP), albumin (ALB), and La as meaningful predictors of urosepsis severity. The combined detection indicators hold greater value in diagnosing uroseptic shock compared to individual test indicators. In addition, the study confirmed the prevalence of drug-resistant E. coli in cases of septic shock.

CONCLUSION

The combined monitoring of N%, NLR, La, TP, and ALB proves beneficial in the clinical diagnosis of uroseptic shock. This study emphasizes the significance of monitoring Escherichia coli and its resistance patterns to decrease the occurrence of sepsis complications.