HLA and hydatidiform mole. I. HLA and ABO antigen frequencies in couples with androgenetic and diandric conceptuses.

HLA and ABO antigen frequencies and mating rates were studied in couples with hydatidiform mole with known genomic origin. HLA-A,B antigen frequencies among 60 patients and 59 spouses were not different from those found in the background population, neither in the subgroups regarded alone nor in the entire series. Although not significant, an excess of HLA-DRw6 found in patients with androgenetic conceptions may be related to the anucleate ovi observed with androgenesis. The distribution of ABO blood groups was in accordance with that observed in the background population; however, an overall excess of A x O matings was found.