Journal of neuroimmunology · 2010
Restoration of microglial function by granulocyte-colony stimulating factor in ALS model mice.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Yamasaki Ryo, Tanaka Masahito, Fukunaga Mami, Tateishi Takahisa, Kikuchi Hitoshi, Motomura Kyoko, Matsushita Takuya, Ohyagi Yasumasa, Kira Jun-ichi
Аннотация
We studied the effects of G-CSF on microglial reactions in mutant SOD1 (mSOD1)-Tg (G93A) ALS model mice. Following hypoglossal axotomy, the numbers of neurons and microglia expressing GDNF were significantly lower in mSOD1-Tg mice than in non-transgenic (NTG) littermates. This decrease in the number of neurons after axotomy and a decrease in the number of large myelinated axons in mSOD1-Tg mice over the disease course were improved by G-CSF, which also increased microglial recruitment. Impaired migration of cultured mSOD1-Tg microglia to MCP-1 was recovered following G-CSF treatment. Restoration of microglial responses by G-CSF may contribute to its neuroprotective effects.
Предметные рубрики MeSH
Adenosine TriphosphateAmyotrophic Lateral SclerosisAnimalsAxotomyBrain-Derived Neurotrophic FactorCell CountCell MovementCells, CulturedDisease Models, AnimalDisease ProgressionGene Expression RegulationGlial Cell Line-Derived Neurotrophic FactorGranulocyte Colony-Stimulating FactorHumansHypoglossal NerveHypoglossal Nerve InjuriesMacrophagesMaleMiceMice, Inbred C57BLMice, TransgenicMicrogliaMotor NeuronsNF-kappa BNerve DegenerationRecovery of FunctionSTAT3 Transcription FactorSignal TransductionSpinal CordSuperoxide Dismutase