European journal of case reports in internal medicine · 2018
Thymic Carcinoma Associated with Cerebellar Degeneration.
СтатьяНазвание и аннотация: Перевод в очереди
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Cuartero Irene García, Galdeano Monica Rodríguez, Pinar Montserrat Pérez, Del Pozo Julián Solís García
Аннотация
UNLABELLED: We present the case of a 57-year-old man with ataxia and clinical and radiological features of cerebellar degeneration. Computed tomography showed a mediastinal mass and the patient was diagnosed with thymic carcinoma. Paraneoplastic cerebellar degeneration is aninfrequent disorder and its association with thymic carcinoma very rare.
LEARNING POINTS: Unexplained subacute neurological symptoms in an adult patient should beconsidered in the possibility of a paraneoplastic syndrome. In patients over 50 years of age, acute or subacute cerebellar degeneration is paraneoplastic in 50% of cases.Small-cell lung cancer is the most common cancer-causing paraneoplastic cerebellar degeneration (PCD). Despite this, mediastinal tumours such as thymus neoplasms should not be ruled out in the differential diagnosis.Antineuronal antibodies are not detected in 40% of patients with PCD, sothe exclusion of other aetiologies or the demonstration of cancer formsthe basis of the final diagnosis.
LEARNING POINTS: Unexplained subacute neurological symptoms in an adult patient should beconsidered in the possibility of a paraneoplastic syndrome. In patients over 50 years of age, acute or subacute cerebellar degeneration is paraneoplastic in 50% of cases.Small-cell lung cancer is the most common cancer-causing paraneoplastic cerebellar degeneration (PCD). Despite this, mediastinal tumours such as thymus neoplasms should not be ruled out in the differential diagnosis.Antineuronal antibodies are not detected in 40% of patients with PCD, sothe exclusion of other aetiologies or the demonstration of cancer formsthe basis of the final diagnosis.