Epigenomics · 2019
Zika virus alters DNA methylation status of genes involved in Hippo signaling pathway in human neural progenitor cells.
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Kandilya Deepika, Maskomani Silambarasan, Shyamasundar Sukanya, Tambyah Paul Anantharajah, Shiao Yng Chan, Lee Regina Ching Hua, Hande Manoor Prakash, Mallilankaraman Karthik, Chu Justin Jang Hann, Dheen S Thameem
Аннотация
Aim: This study was aimed to understand if Zika virus (ZIKV) alters the DNA methylome of human neural progenitor cells (hNPCs). Materials & methods: Whole genome DNA methylation profiling was performed using human methylationEPIC array in control and ZIKV infected hNPCs. Results & conclusion: ZIKV infection altered the DNA methylation of several genes such as WWTR1 (TAZ) and RASSF1 of Hippo signaling pathway which regulates organ size during brain development, and decreased the expression of several centrosomal-related microcephaly genes, and genes involved in stemness and differentiation in human neural progenitor cells. Overall, ZIKV downregulated the Hippo signaling pathway genes which perturb the stemness and differentiation process in hNPCs, which could form the basis for ZIKV-induced microcephaly.
Предметные рубрики MeSH
BiomarkersCell DifferentiationCells, CulturedDNA MethylationGene Expression RegulationHippo Signaling PathwayHumansNeural Stem CellsProtein Serine-Threonine KinasesSignal TransductionTrans-ActivatorsTranscriptional Coactivator with PDZ-Binding Motif ProteinsTumor Suppressor ProteinsZika VirusZika Virus Infection