cAMP and cGMP (EVE) changes in immune competent cells under sensibilization and anaphylactic shock of animals of different age.

The studies performed proved that there were no substantial differences in intracellular content of cAMP and cGMP in immune systems of both old and young animals. The influence of equine serum upon lymphocytes in accompanied by the most substantial changes in concentrations of cyclic nucleotides in spleen B-cells. The amplitude of level changes in cAMP and cGMP in these cells under anaphylactic shock doubles the value of old animals. Thus together with genetically preprogrammed change in functional activity of immune competent cells, expressed in different force of immune response, the correlative changes in cyclase system of animals of different ages have been observed.