Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery · 2007
[Differential expression of CD133, Glut-1 in tissues and endothelial cells derived from infantile hemangioma and vascular malformation].
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Li Na, Wang Yu-rong, Zhong Ai-mei, Wang Wen-juan
Аннотация
OBJECTIVE: To investigate the expression and significance of CD133, Glut-1 and precursor cell, placental microvessel endothelial cells in the occurrence, development and regression of infantile hemangiomas.
METHODS: We examined the expression and significance of CD133, Glut-1 in the occurrence, development and regression of infantile hemangiomas and congenital vascular malformation postnatal vascular malformation using immunohistochemical technique. An image analysis system (Image-pro plus 5.0) was used to measure the average integrated optical density and the rate of positive area of CD133 and Glut-i in different stages of hemangiomas and in vascular malformation.
RESULTS: The expression of CD133 was significantly higher in differential stages congenital hemangioma, congenital vascular malformation, placenta chorionic villi than postnatal vascular malformation (P < 0.05). About the expression of Glut-1, there was difference between proliferating hemangiomas, placenta and degenerating hemangiomas, vascular malformation (P < 0.05).
CONCLUSION: The precursor cells marked CD133 is the source of endothelial cells derived from congenital hemangiomas and congenital vascular malformation.
METHODS: We examined the expression and significance of CD133, Glut-1 in the occurrence, development and regression of infantile hemangiomas and congenital vascular malformation postnatal vascular malformation using immunohistochemical technique. An image analysis system (Image-pro plus 5.0) was used to measure the average integrated optical density and the rate of positive area of CD133 and Glut-i in different stages of hemangiomas and in vascular malformation.
RESULTS: The expression of CD133 was significantly higher in differential stages congenital hemangioma, congenital vascular malformation, placenta chorionic villi than postnatal vascular malformation (P < 0.05). About the expression of Glut-1, there was difference between proliferating hemangiomas, placenta and degenerating hemangiomas, vascular malformation (P < 0.05).
CONCLUSION: The precursor cells marked CD133 is the source of endothelial cells derived from congenital hemangiomas and congenital vascular malformation.