[Differential expression of CD133, Glut-1 in tissues and endothelial cells derived from infantile hemangioma and vascular malformation].

OBJECTIVE

To investigate the expression and significance of CD133, Glut-1 and precursor cell, placental microvessel endothelial cells in the occurrence, development and regression of infantile hemangiomas.

METHODS

We examined the expression and significance of CD133, Glut-1 in the occurrence, development and regression of infantile hemangiomas and congenital vascular malformation postnatal vascular malformation using immunohistochemical technique. An image analysis system (Image-pro plus 5.0) was used to measure the average integrated optical density and the rate of positive area of CD133 and Glut-i in different stages of hemangiomas and in vascular malformation.

RESULTS

The expression of CD133 was significantly higher in differential stages congenital hemangioma, congenital vascular malformation, placenta chorionic villi than postnatal vascular malformation (P < 0.05). About the expression of Glut-1, there was difference between proliferating hemangiomas, placenta and degenerating hemangiomas, vascular malformation (P < 0.05).

CONCLUSION

The precursor cells marked CD133 is the source of endothelial cells derived from congenital hemangiomas and congenital vascular malformation.