Attenuation of cocaine-induced elevation of nucleus accumbens dopamine in lead-exposed rats.

Fourteen adult male rats were placed on an ad lib watering regimen where they received water containing 500 ppm lead acetate (group lead) or an equivalent concentration of sodium acetate (group control) for 61 days. Subsequently, a microdialysis cannula was surgically implanted in the nucleus accumbens. Following recovery, the seven animals in group lead and the seven animals in group control were presented with a challenge of 10 mg/kg cocaine HCL (IP). Dopamine efflux was measured prior to and at 20, 40, and 60 min postinjection, using HPLC technology. The results of this experiment showed that cocaine caused a significantly greater increase in extracellular nucleus accumbens dopamine in control animals relative to lead-treated animals.