Two new polyketides isolated from the endophytic fungus Phomopsis heveicola POH-zhi and its antifungal activity.

Two new polyketides, demethyl-epiremisporine B (1) and demethyl-coniochaetone A (2), together with four known polyketide compounds including diaportheone A (3), vertixanthone (4), peniphenone (5) and 3,8-dihydroxy-1-propylanthraquinone (6), were isolated from the endophytic fungus Phomopsis heveicola obtained from Sterculia lychnophora. The structures of the new metabolites were elucidated by NMR and HRESIMS analysis, and the absolute configuration of compound 1 was established by ECD spectroscopy. These compounds were evaluated for their antifungal activity against Candida albicans CMCC 98001 and Aspergillus niger R330. Compounds 4 and 6 showed significant antifungal activity on C. Albicans CMCC 98001, with the MIC of 3.125 μg/ml.