Journal of ethnopharmacology · 2025
Anti-inflammatory effect of free and microencapsulated extract of Lippia graveolens Kunth in a carrageenan-induced paw edema model and an ovalbumin-induced asthma model in mice.
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Bernal-Millán Manuel J, Roa-Coria José E, Flores-Murrieta Francisco J, Huerta-Cruz Juan C, Gutiérrez-Grijalva Erick P, León-Félix Josefina, Angulo-Escalante Miguel A, Heredia J Basilio, Carrasco-Portugal Miriam C
Аннотация
ETHNOPHARMACOLOGICAL RELEVANCE: Lippia graveolens Kunth has been widely used in traditional Mexican medicine to relieve stomach pain, menstrual pain, and respiratory illnesses (flu and cough). However, its anti-inflammatory effect has not been studied in acute and chronic inflammation models.
AIM OF THE STUDY: to evaluate the effect of L. graveolens Kunth extract and microcapsules against paw and airway inflammation.
MATERIALS AND METHODS: Paw edema in mice was induced with carrageenan, while allergic asthma was sensitized and challenged with ovalbumin. L. graveolens Kunth samples were orally administered to mice in 30, 100, 300, 560, and 717 mg/kg doses to evaluate edema size, while for the following tests, the 560 mg/kg dose was administered. Inflammatory cell count, serum IgE level, and detection of proinflammatory cytokine levels in serum, plantar tissue, and lung tissue were analyzed.
RESULTS: Edema thickness measurement revealed that L. graveolens Kunth reduces paw inflammation and could potentially be anti-inflammatory in acute and chronic inflammation. Treatments with L. graveolens Kunth significantly decreased the number of inflammatory cells in the blood, the production of IgE in serum, and the cytokines IL-1β, IL-6, and TNF-α levels in serum, paw, and lungs.
CONCLUSIONS: These findings suggest that L. graveolens Kunth has an anti-inflammatory effect on carrageenan-induced paw edema and ovalbumin-induced allergic asthma in mice and might be a promising protective agent for inflammatory diseases.
AIM OF THE STUDY: to evaluate the effect of L. graveolens Kunth extract and microcapsules against paw and airway inflammation.
MATERIALS AND METHODS: Paw edema in mice was induced with carrageenan, while allergic asthma was sensitized and challenged with ovalbumin. L. graveolens Kunth samples were orally administered to mice in 30, 100, 300, 560, and 717 mg/kg doses to evaluate edema size, while for the following tests, the 560 mg/kg dose was administered. Inflammatory cell count, serum IgE level, and detection of proinflammatory cytokine levels in serum, plantar tissue, and lung tissue were analyzed.
RESULTS: Edema thickness measurement revealed that L. graveolens Kunth reduces paw inflammation and could potentially be anti-inflammatory in acute and chronic inflammation. Treatments with L. graveolens Kunth significantly decreased the number of inflammatory cells in the blood, the production of IgE in serum, and the cytokines IL-1β, IL-6, and TNF-α levels in serum, paw, and lungs.
CONCLUSIONS: These findings suggest that L. graveolens Kunth has an anti-inflammatory effect on carrageenan-induced paw edema and ovalbumin-induced allergic asthma in mice and might be a promising protective agent for inflammatory diseases.