Increase in urinary markers during the acute phase reflects the degree of chronic tubulointerstitial injury after ischemia-reperfusion renal injury.

CONTEXT: Acute kidney injury (AKI) could lead to progressive chronic kidney disease (CKD).

OBJECTIVES

To demonstrate that urinary markers in AKI are associated with the degree of persistent renal injury.

MATERIAL AND

METHODS

Human L-FABP chromosomal transgenic (Tg) mice were subjected to ischemia-reperfusion (I/R) clamping renal pedicle for 20 min or 30 min. Kidneys were obtained at one and 40 days after I/R.

RESULTS

Urinary L-FABP, NGAL, Kim-1 and albumin levels increased during the acute phase and were significantly correlated with the degree of tubulointerstitial fibrosis during the chronic phase.

DISCUSSION AND

CONCLUSION

These markers could detect higher risk of progression to CKD.