Internal medicine (Tokyo, Japan) · 1993
Integrin VLA-5 negative primary plasma cell leukemia.
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Ohtake K, Takeuchi T, Saito K, Ito T, Ito I, Aoki K, Takano Y, Amano K, Hosono O, Koide J
Аннотация
We present a case of primary plasma cell leukemia with Bence Jones proteinuria. After combination chemotherapy, leukemic cells and the urinary levels Bence Jones protein were decreased. Small lytic bone lesions were detected only in the skull. Typical plasma cells were rarely seen in peripheral blood on the hyperleukocytic phase, however they were increased in the advanced stages. The most important diagnostic sign was persistent expression of CD38 antigen on leukemic cells throughout the entire course of the illness and these leukemic cells expressed very late antigen-4 (VLA-4) but not VLA-5.
Предметные рубрики MeSH
ADP-ribosyl CyclaseADP-ribosyl Cyclase 1AgedAntigens, CDAntigens, DifferentiationAntigens, NeoplasmAntineoplastic Combined Chemotherapy ProtocolsBence Jones ProteinBone MarrowCyclophosphamideDoxorubicinFatal OutcomeFemaleHumansLeukemia, Plasma CellMembrane GlycoproteinsNeoplasm ProteinsNeoplastic Stem CellsOsteolysisPrednisoloneReceptors, FibronectinVincristine