[Safety of the use of Celsior in kidney-pancreas transplantation].

UNLABELLED: The objective of this prospective observation study was to evaluate the safety of use of Celsior extracellular solution, initially designed for cardiac preservation, in kidney-pancreas transplantation.

PATIENTS AND

METHODS

From August 1999 to July 2000, 140 kidneys and 9 pancreases were harvested from 71 cadaveric donors with a mean age of 34 +/- 11 years, washed and preserved until transplantation with Celsior. One hundred and thirty one isolated renal transplantations and 9 combined kidney-pancreas transplantations were performed. The mean age of isolated kidney recipients and kidney-pancreas recipients was 42 +/- 13 years (range: 4-71 years) and 39 +/- 7 years (range: 31-52 years), respectively. The mean cold ischaemia time was 21 +/- 8 hours (range: 4-45) for kidneys and 11.43 +/- 2.9 hours (range: 6-15 hours) for pancreases.

RESULTS

No cardiac or haemodynamic incidents were observed during organ revascularization. No electrolyte or haematological abnormalities were observed postoperatively. The one-year graft survival rate was 96% (range: 93%-99%) for kidneys and 89% (range: 55%-100%) for pancreases. Patient survival was 100%. Return of renal transplant function was delayed in 14% (8-20%) of patients, requiring dialysis during the first week. Mean serum creatinine at 3 months and at 1 year was 123 +/- 41 mumol/l and 118.5 +/- 33.8 mumol/l, respectively. One pancreas and one kidney were lost due to venous thrombosis on D2 and D4. Two patients in the kidney-pancreas group were reoperated.