Journal of B.U.ON. : official journal of the Balkan Union of Oncology · 2010
Prognostic and predictive factors of invasive ductal breast carcinomas.
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Lialiaris T S, Georgiou G, Sivridis E, Kareli D, Tripsiannis G, Papageorgiou A, Chrisafi S, Kritsi Z, Giatromanolaki A
Аннотация
PURPOSE: To investigate the significance of certain immunohistochemical markers, namely estrogen (ER) and progesterone receptors (PgR), c-erbB-2 oncogene, p53 tumor suppressor gene and E-cadherin adhesion molecule, in invasive ductal breast carcinomas.
METHODS: A series of 102 primary breast carcinomas of the ductal type and a standard immunohistochemical technique was used to detect the aforementioned biological markers. The findings were related to various clinical and pathological tumor characteristics, including lymph node metastases.
RESULTS: ER and E-cadherin were expressed more commonly in tumors of low histological grade and small number (< or =3) of metastatic lymph nodes, whereas c-erbB-2 and the p53 gene were usually expressed in breast tumors of high histological grade and increased number (>3) of metastatic lymph nodes. PgR, on the other hand, was detected frequently in patients with early menarche and metastases in <3 lymph nodes, but this tendency was not statistically significant.
CONCLUSION: The use of these biomarkers, preferably in combination, may provide additional prognostic and therapeutic information which may be proved useful in planning breast cancer treatment.
METHODS: A series of 102 primary breast carcinomas of the ductal type and a standard immunohistochemical technique was used to detect the aforementioned biological markers. The findings were related to various clinical and pathological tumor characteristics, including lymph node metastases.
RESULTS: ER and E-cadherin were expressed more commonly in tumors of low histological grade and small number (< or =3) of metastatic lymph nodes, whereas c-erbB-2 and the p53 gene were usually expressed in breast tumors of high histological grade and increased number (>3) of metastatic lymph nodes. PgR, on the other hand, was detected frequently in patients with early menarche and metastases in <3 lymph nodes, but this tendency was not statistically significant.
CONCLUSION: The use of these biomarkers, preferably in combination, may provide additional prognostic and therapeutic information which may be proved useful in planning breast cancer treatment.
Предметные рубрики MeSH
AdultAge FactorsAgedAged, 80 and overAntigens, CDBiomarkers, TumorBody WeightBreast NeoplasmsCadherinsCarcinoma, Ductal, BreastChi-Square DistributionFemaleGreeceHumansImmunohistochemistryLymphatic MetastasisMiddle AgedNeoplasm StagingOdds RatioPredictive Value of TestsPrognosisErb-b2 Receptor Tyrosine KinasesReceptors, EstrogenReceptors, ProgesteroneRisk AssessmentRisk FactorsTumor Suppressor Protein p53