Cutaneous Manifestations of Chronic Renal Failure.

Cutaneous manifestations of chronic renal failure (CRF) were studied in 20 cases. Generalised pruritus was observed in 8 patients, ichthyotic skin changes of varying degree in 18 patients and hyperpigmentation of sun-exposed skin in 7 patients. Scaling, pallor and hair loss correlated strongly with the severity of CRF. Skin biopsy performed in 5 cases revealed mild hyperkeratosis, reduction of prickle cell layer and flattening of rate ridges. No significant dermal changes were detected.