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DOI 10.2217/pgs-2020-0028

Медицинская библиотека · Pharmacogenomics · 2020

Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment.

Pisanu Claudia, Congiu Donatella, Manchia Mirko, Caria Paola, Cocco Cristina, Dettori Tinuccia, Frau Daniela Virginia, Manca Elias, Meloni Anna, Nieddu Mariella, Noli Barbara, Pinna Federica, Robledo Renato, Sogos Valeria, Ferri Gian Luca, Carpiniello Bernardo, Vanni Roberta, Bocchetta Alberto, Severino Giovanni, Ardau Raffaella, Chillotti Caterina, Zompo Maria Del, Squassina Alessio

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Aim: To assess the role of lithium treatment in the relationship between bipolar disorder (BD) and leukocyte telomere length (LTL). Materials & methods: We compared LTL between 131 patients with BD, with or without a history of lithium treatment, and 336 controls. We tested the association between genetically determined LTL and BD in two large genome-wide association datasets.

Results

Patients with BD with a history lithium treatment showed longer LTL compared with never-treated patients (p = 0.015), and similar LTL compared with controls. Patients never treated with lithium showed shorter LTL compared with controls (p = 0.029). Mendelian randomization analysis showed no association between BD and genetically determined LTL.

Conclusion

Our data support previous findings showing that long-term lithium treatment might protect against telomere shortening.

Для цитирования: Pisanu Claudia, Congiu Donatella, Manchia Mirko, Caria Paola, Cocco Cristina, Dettori Tinuccia, Frau Daniela Virginia, Manca Elias, Meloni Anna, Nieddu Mariella, Noli Barbara, Pinna Federica, Robledo Renato, Sogos Valeria, Ferri Gian Luca, Carpiniello Bernardo, Vanni Roberta, Bocchetta Alberto, Severino Giovanni, Ardau Raffaella, Chillotti Caterina, Zompo Maria Del, Squassina Alessio. Differences in telomere length between patients with bipolar disorder and controls are influenced by lithium treatment.. Pharmacogenomics. 2020. DOI: 10.2217/pgs-2020-0028.

Предметные рубрики MeSH

AdultAntidepressive AgentsBipolar DisorderFemaleGenome-Wide Association StudyHumansLeukocytesLithium CompoundsLongitudinal StudiesMaleMiddle AgedTelomereTelomere ShorteningTreatment Outcome
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