Type I diabetic nephropathy: clinical characteristics and economic impact.

Approximately one-third of type I diabetic patients develop diabetic nephropathy with confounding pathogenesis--frequently manifested as heavy persistent proteinuria, fall in glomerular filtration rate, and increased arterial hypertension. There is increasing incidence and prevalence of type I diabetes, particularly in northern Europe and the United States. Increased morbidity and mortality occur in type I diabetic patients with renal disease. Among type I patients with persistent proteinuria, death occurs on the average within 5-10 years. The economic impact of endstage renal disease due to diabetic nephropathy is overwhelming, and the cost is increasing at an alarming rate.