[Results of histological evaluation of glandular epithelium in BPH in hypo- and eugonadal men].

INTRODUCTION

Benign prostatic hyperplasia (BPH), despite advances in pharmacotherapy and surgical treatment, remains a pressing problem in modern urology. The success of therapy depends on the condition of the prostate epithelial compartment.

OBJECTIVE

To conduct a histological assessment of glandular epithelium in BPH in hypo- and eugonadal men.

MATERIALS AND

METHODS

The results of morphological examination of the resected prostate tissue of 188 men with BPH were analyzed, who were divided into two groups: Group I - 71 patients with testosterone (Tc) deficiency, group II (control) - 117 patients with testosterone levels above 12.1 nmol/L.

RESULTS

In patients with Tc deficiency, morphological examination of resected prostate tissue samples revealed a stromal pattern of BPH, combined with cystic deformation of the acini, with flattened and non-secretory epithelium. In patients with normal Tc levels, all patients had a glandular pattern of hyperplasia, and the epithelial cells of the acini were tall, columnar, and showed signs of active secretion.

CONCLUSIONS

In patients with testosterone deficiency, morphological examination of resected prostate tissue samples revealed atrophic, flattened, and non-secretory epithelium. In patients with Tc levels within the reference range, all epithelial cells were tall, columnar, and showed signs of active secretion.