Evaluation of Monocyte-lymphocyte-ratios, Changes of Patterns in Different Stages of Chronic Kidney Disease, Risks and Progression.

BACKGROUND

Chronic kidney disease (CKD) is capital-intensive and challenging to manage, thus, a need for a cost-effective and accessible marker. Monocyte lymphocyte ratio (MLR), a subset of leukocytes, is valuable as a surrogate tool of chronic systemic inflammation in evaluating and assessing CKD stages and complications. Elevated MLR is associated with worsening systemic inflammation and immune dysfunction in CKD.

AIM: To determine whether increase in MLR correlates with progression in CKD stages.

SUBJECT AND

METHODS

Evaluate the relationship between the MLR and CKD stages. Cross-sectional. Tertiary care centre in Lagos, Nigeria. This is a cross-sectional study of 300 patients with CKD attending a teaching hospital in Lagos, Nigeria, conducted between January 2024 and July 2024. The patients' CKD stages were evaluated using the modification of diet in renal disease to calculate their estimated glomerular filtration rate with their corresponding MLR retrieved from their full blood count results. The data were analysed using the SPSS software version 23.0. The statistical significance was set at a P < 0.05.

RESULTS

The mean age was 58.5 (5.7) with a male-female ratio of 1.6:1. The average MLR was 0.44 (0.14) the correlation between CKD stages and MLR was (r = 0.763, P = 0.001) subjects in CKD 2 and 3 compared to those on dialysis were 27.4 times likely to fall in fourth quartile of MLR.

CONCLUSION

Our study revealed that elevated MLR, an inflammatory marker, was strongly associated with worsening renal function across all CKD stages.