International immunopharmacology · 2009
Serum adipsin levels in patients with seasonal allergic rhinitis: preliminary data.
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Ciprandi Giorgio, De Amici Mara, Marseglia Gianluigi
Аннотация
BACKGROUND: Several studies have outlined a possible relationship between adipokines and respiratory allergic diseases. However, there are no data about a role for adipsin in allergic rhinitis.
OBJECTIVE: The aim of the study was to evaluate the serum adipsin levels in patients with seasonal allergic rhinitis (SAR), subdivided into two sub-groups: treated or not treated with sublingual immunotherapy (SLIT), and in a group of healthy controls.
METHODS: The study included 110 subjects; i) 24 SLIT-treated SAR patients, ii) 62 untreated SAR patients, and iii) 24 normal subjects. All subjects were consecutively evaluated. A skin prick test and blood sampling for assessing serum adipsin levels were performed in all subjects.
RESULTS: Serum adipsin was increased in SAR patients, even though significant only in males. There was also a significant positive association between adipsin and adiponectin.
CONCLUSION: This preliminary study reports that adipsin serum levels may be increased in some SAR patients, but further functional studies should be performed.
OBJECTIVE: The aim of the study was to evaluate the serum adipsin levels in patients with seasonal allergic rhinitis (SAR), subdivided into two sub-groups: treated or not treated with sublingual immunotherapy (SLIT), and in a group of healthy controls.
METHODS: The study included 110 subjects; i) 24 SLIT-treated SAR patients, ii) 62 untreated SAR patients, and iii) 24 normal subjects. All subjects were consecutively evaluated. A skin prick test and blood sampling for assessing serum adipsin levels were performed in all subjects.
RESULTS: Serum adipsin was increased in SAR patients, even though significant only in males. There was also a significant positive association between adipsin and adiponectin.
CONCLUSION: This preliminary study reports that adipsin serum levels may be increased in some SAR patients, but further functional studies should be performed.