Pregnancy and perinatal outcomes among women with multiple sclerosis: a retrospective case-controlled study in South Hungary.

OBJECTIVE

The aim of this study was to investigate the connections between multiple sclerosis (MS) and fertility, pregnancy.

METHODS

The case histories and pregnancy complications in a sample of 65 treatment-naive pregnant women with MS in the period 1998-2012 were compared with an age-matched case-controlled analysis. Comparisons were made between primigravidas and multigravidas subjects.

RESULTS

Our results revealed a higher rate of miscarriage (18.46%) in the first trimester in women with MS, and intrauterine death (7.69%) in the third trimester, as compared with women without MS (p < 0.001 and p = 0.035).

CONCLUSIONS

These findings suggest that, the risk of miscarriages and intrauterine death may be disease-related not drug-related feature. Further studies are needed to determine to possible associated factors of miscarriages.