Journal of rehabilitation medicine · 2025
From gains to decline: effects of structured pre-dialytic exercise training and detraining on physical fitness, quality of life, and inflammation in haemodialysis patients.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Huang Shu-Chun, Fang Ji-Tseng, Huang Yu-Chieh, Lin Chun-Yueh, Hsiao Ching-Chung
Аннотация
OBJECTIVE: Pre-dialysis exercise training may benefit haemodialysis patients, but the effects of structured aerobic and resistance training remain unclear. This study evaluated the effects of a 6-month training performed 1-2 h before haemodialysis on muscle strength, cardiorespiratory fitness, quality of life, and systemic inflammation.
DESIGN: A 3-phase self-controlled design: 3-month control, 6-month aerobic and resistance training (72 sessions) and nutrition counselling, and 3-month follow-up.
PATIENTS: Haemodialysis patients > 3 months.
METHODS: Assessments were performed every 3 months at 5 time points. Outcomes included physical fitness (dual-energy X-ray absorptiometry, isokinetic dynamometry, and cardiopulmonary exercise testing), Kidney Disease QOL questionnaire, International Physical Activity Questionnaire, nutrition, and plasma pro- and anti-inflammatory cytokines.
RESULTS: Of 118 patients screened, 29 entered training and 22 completed 72 sessions (92% compliance). Pre-dialysis exercise training improved muscle mass, cardiorespiratory fitness, quadriceps strength, physical and mental components, and disease-specific quality of life; cardiorespiratory fitness and strength declined at 3-month follow-up, but muscle mass remained. Cytokine levels were unchanged, suggesting minimal pro- or anti-inflammatory effects.
CONCLUSION: A 6-month pre-dialysis exercise programme improved cardiorespiratory fitness, strength, muscle mass, and quality of life with high compliance. It may be viable for haemodialysis patients, though maintenance is needed to sustain benefits.
CLINICALTRIALS: gov ID: NCT05649657.
DESIGN: A 3-phase self-controlled design: 3-month control, 6-month aerobic and resistance training (72 sessions) and nutrition counselling, and 3-month follow-up.
PATIENTS: Haemodialysis patients > 3 months.
METHODS: Assessments were performed every 3 months at 5 time points. Outcomes included physical fitness (dual-energy X-ray absorptiometry, isokinetic dynamometry, and cardiopulmonary exercise testing), Kidney Disease QOL questionnaire, International Physical Activity Questionnaire, nutrition, and plasma pro- and anti-inflammatory cytokines.
RESULTS: Of 118 patients screened, 29 entered training and 22 completed 72 sessions (92% compliance). Pre-dialysis exercise training improved muscle mass, cardiorespiratory fitness, quadriceps strength, physical and mental components, and disease-specific quality of life; cardiorespiratory fitness and strength declined at 3-month follow-up, but muscle mass remained. Cytokine levels were unchanged, suggesting minimal pro- or anti-inflammatory effects.
CONCLUSION: A 6-month pre-dialysis exercise programme improved cardiorespiratory fitness, strength, muscle mass, and quality of life with high compliance. It may be viable for haemodialysis patients, though maintenance is needed to sustain benefits.
CLINICALTRIALS: gov ID: NCT05649657.