JACC. Basic to translational science · 2022
Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics.
СтатьяНазвание и аннотация: Перевод в очереди
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Roh Jason D, Kitchen Robert R, Guseh J Sawalla, McNeill Jenna N, Aid Malika, Martinot Amanda J, Yu Andy, Platt Colin, Rhee James, Weber Brittany, Trager Lena E, Hastings Margaret H, Ducat Sarah, Xia Peng, Castro Claire, Singh Abhilasha, Atlason Bjarni, Churchill Timothy W, Di Carli Marcelo F, Ellinor Patrick T, Barouch Dan H, Ho Jennifer E, Rosenzweig Anthony
Аннотация
To gain insights into the mechanisms driving cardiovascular complications in COVID-19, we performed a case-control plasma proteomics study in COVID-19 patients. Our results identify the senescence-associated secretory phenotype, a marker of biological aging, as the dominant process associated with disease severity and cardiac involvement. FSTL3, an indicator of senescence-promoting Activin/TGFβ signaling, and ADAMTS13, the von Willebrand Factor-cleaving protease whose loss-of-function causes microvascular thrombosis, were among the proteins most strongly associated with myocardial stress and injury. Findings were validated in a larger COVID-19 patient cohort and the hamster COVID-19 model, providing new insights into the pathophysiology of COVID-19 cardiovascular complications with therapeutic implications.