British journal of pharmacology · 2013
HDAC inhibitors restore C-fibre sensitivity in experimental neuropathic pain model.
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Matsushita Yosuke, Araki Kohei, Omotuyi Olaposi idowu, Mukae Takehiro, Ueda Hiroshi
Аннотация
BACKGROUND AND PURPOSE: Hypoesthesia is a clinical feature of neuropathic pain. The feature is partly explained by the evidence of epigenetic repression of Nav 1.8 sodium channel in the dorsal root ganglion (DRG).
EXPERIMENTAL APPROACH: We investigated the possibility of trichostatin A (TSA), valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA) to reverse the unique C-fibre sensitivity observed following partial ligation of sciatic nerve in mice.
KEY RESULTS: Nerve injury-induced down-regulation of DRG Nav 1.8 sodium channel and C-fibre-related hypoesthesia were reversed by TSA, VPA and SAHA treatments, which inhibit histone deacetylase (HDAC), and increase histone acetylation at the regulatory sequence of Nav 1.8.
CONCLUSIONS AND IMPLICATIONS: Taken together, these studies provide the evidence that hypoesthesia and underlying down-regulation of Nav 1.8, negative symptoms observed in nerve injury-induced neuropathic pain models are regulated by an epigenetic chromatin remodelling through HDAC-related machineries.
EXPERIMENTAL APPROACH: We investigated the possibility of trichostatin A (TSA), valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA) to reverse the unique C-fibre sensitivity observed following partial ligation of sciatic nerve in mice.
KEY RESULTS: Nerve injury-induced down-regulation of DRG Nav 1.8 sodium channel and C-fibre-related hypoesthesia were reversed by TSA, VPA and SAHA treatments, which inhibit histone deacetylase (HDAC), and increase histone acetylation at the regulatory sequence of Nav 1.8.
CONCLUSIONS AND IMPLICATIONS: Taken together, these studies provide the evidence that hypoesthesia and underlying down-regulation of Nav 1.8, negative symptoms observed in nerve injury-induced neuropathic pain models are regulated by an epigenetic chromatin remodelling through HDAC-related machineries.
Предметные рубрики MeSH
AcetylationAnalgesicsAnimalsChromatin Assembly and DisassemblyDisease Models, AnimalEpigenesis, GeneticGanglia, SpinalHistone Deacetylase InhibitorsHistone DeacetylasesHistonesHydroxamic AcidsHypesthesiaLigationMaleMiceMice, Inbred C57BLNAV1.8 Voltage-Gated Sodium ChannelNerve Fibers, UnmyelinatedPain MeasurementPain ThresholdSciatic NerveSciatic NeuropathyTime FactorsValproic AcidVorinostat