[Fundamental and clinical studies of piperacillin in the field of obstetrics and gynecology].

Human pharmacokinetics and clinical studies of piperacillin (PIPC) were carried out and the following results were obtained. 1. Transference into various uterine tissues PIPC transference into various uterine tissues was 27.3 approximately 67.9% (the ratio with respect to uterine artery blood level) at 1 hour after the completion of PIPC 1 or 2g dripping infusion for 1 hour in 5 cases. 2. Transference into retroperitoneal space exudate PIPC level in retroperitoneal space exudate showed the peak level 38.0 micrograms/ml at 30 minutes after the completion of PIPC 2g dripping infusion for 1 hour in 1 case. The pattern of the concentration trends was more continuous than that of venous blood level. 3. Clinical study We administered PIPC to 5 patients with pelveoperitonitis in 3 cases, puerperal fever in 1 case and wound infection in 1 case at a dose of 4 g per day (twice a day) for a period of 5 approximately 9 days. The clinical effect was excellent in 1, good in 3 and poor in 1 case. Neither side effects nor abnormality of laboratory findings were observed.