Brazilian journal of otorhinolaryngology · 2015
The role of aspirin desensitization in patients with aspirin-exacerbated respiratory disease (AERD).
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Spies Jonas Willian, Valera Fabiana Cardoso Pereira, Cordeiro Daniel Loiola, de Mendonça Taís Nociti, Leite Marcelo Gonçalves Junqueira, Tamashiro Edwin, Arruda Luiza Karla, Anselmo-Lima Wilma Terezinha
Аннотация
INTRODUCTION: Aspirin-exacerbated respiratory disease (AERD) consists of a classic tetrad: moderate/severe asthma, chronic rhinosinusitis, nasal polyps, and intolerance to aspirin or other nonsteroidal anti-inflammatory drugs. Clinical control with drugs, surgery, and desensitization are treatment options.
OBJECTIVE: To evaluate the efficacy and tolerability of aspirin desensitization in patients with AERD.
METHODS: Periodic symptom assessment and endoscopy in patients with AERD undergoing surgery who were desensitized.
RESULTS: Seventeen patients were desensitized. Eight patients completed the desensitization and were followed for a minimum of a one-year period (mean 3.1 years). These patients showed improvement in all symptoms. Moreover, surgical reassessment was not indicated in any of these patients and there was a decrease in costs with medication and procedures. Eight patients did not complete desensitization, mainly due to procedure intolerance and uncontrolled asthma, whereas another patient was lost to follow-up.
CONCLUSION: Aspirin desensitization, when tolerated, was effective in patients with AERD and with poor clinical/surgical response.
OBJECTIVE: To evaluate the efficacy and tolerability of aspirin desensitization in patients with AERD.
METHODS: Periodic symptom assessment and endoscopy in patients with AERD undergoing surgery who were desensitized.
RESULTS: Seventeen patients were desensitized. Eight patients completed the desensitization and were followed for a minimum of a one-year period (mean 3.1 years). These patients showed improvement in all symptoms. Moreover, surgical reassessment was not indicated in any of these patients and there was a decrease in costs with medication and procedures. Eight patients did not complete desensitization, mainly due to procedure intolerance and uncontrolled asthma, whereas another patient was lost to follow-up.
CONCLUSION: Aspirin desensitization, when tolerated, was effective in patients with AERD and with poor clinical/surgical response.