iScience · 2024
Pulmonary and renal long COVID at two-year revisit.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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История · было → стало
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Wang Jing, Liang Xiao, Zheng Yufen, Zhu Yi, Zhou Kai, Wu Xiaomai, Sun Rui, Hu Yifan, Zhu Xiaoli, Chi Hongbo, Chen Shanjun, Lyu Mengge, Xie Yuting, Yi Xiao, Liu Wei, Cai Xue, Li Sainan, Zhang Qiushi, Wu Chunlong, Shi Yingqiu, Wang Donglian, Peng Minfei, Zhang Ying, Liu Huafen, Zhang Chao, Quan Sheng, Kong Ziqing, Kang Zhouyang, Zhu Guangjun, Zhu Hongguo, Chen Shiyong, Liang Junbo, Yang Hai, Pang Jianxin, Fang Yicheng, Chen Haixiao, Li Jun, Xu Jiaqin, Guo Tiannan, Shen Bo
Аннотация
This study investigated host responses to long COVID by following up with 89 of the original 144 cohorts for 1-year (N = 73) and 2-year visits (N = 57). Pulmonary long COVID, characterized by fibrous stripes, was observed in 8.7% and 17.8% of patients at the 1-year and 2-year revisits, respectively, while renal long COVID was present in 15.2% and 23.9% of patients, respectively. Pulmonary and renal long COVID at 1-year revisit was predicted using a machine learning model based on clinical and multi-omics data collected during the first month of the disease with an accuracy of 87.5%. Proteomics revealed that lung fibrous stripes were associated with consistent down-regulation of surfactant-associated protein B in the sera, while renal long COVID could be linked to the inhibition of urinary protein expression. This study provides a longitudinal view of the clinical and molecular landscape of COVID-19 and presents a predictive model for pulmonary and renal long COVID.