Children (Basel, Switzerland) · 2025
Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case-Control Study.
СтатьяНазвание и аннотация: Перевод в очереди
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Kyriakopoulou Aikaterini, Samikos Kyriakos, Kanavaki Aikaterini, Alexopoulou Efthymia, Argyropoulou Maria, Psaltopoulou Theodora, Kanaka-Gantenbein Christina, Dinopoulos Argyrios, Giorgi Melpomene, Antoniadou Anastasia, Filippa Iliani, Siafakas Nikolaos, Serghiou Stylianos, Papaevangelou Vassiliki
Аннотация
OBJECTIVE: To investigate the clinical characteristics associated with the presence of LSV at birth.
DESIGN: Prospective 1:1 case-control study.
SETTING: Two tertiary neonatal units in Athens, Greece.
PATIENTS: Premature neonates (≤36 weeks gestational age) who underwent cerebral ultrasound within the first 3 weeks of life, where LSV was detected.
MAIN OUTCOME MEASURE: Associations between LSV and clinical characteristics at birth. Both unmatched and matched analyses stratifying the study population by gestational week were conducted. Two-sided p-values were computed using the likelihood ratio test.
RESULTS: This study included 166 participants (83 cases and 83 controls). Neonates with LSV exhibited more concurrent cerebral findings, notably periventricular echogenicity. LSV was correlated with higher z-scores for head circumference and body length. LSV was not associated with congenital CMV.
CONCLUSIONS: This study indicated a relationship between LSV and increased head circumference and body length. Further research is warranted to explore LSV's pathophysiological mechanisms.
DESIGN: Prospective 1:1 case-control study.
SETTING: Two tertiary neonatal units in Athens, Greece.
PATIENTS: Premature neonates (≤36 weeks gestational age) who underwent cerebral ultrasound within the first 3 weeks of life, where LSV was detected.
MAIN OUTCOME MEASURE: Associations between LSV and clinical characteristics at birth. Both unmatched and matched analyses stratifying the study population by gestational week were conducted. Two-sided p-values were computed using the likelihood ratio test.
RESULTS: This study included 166 participants (83 cases and 83 controls). Neonates with LSV exhibited more concurrent cerebral findings, notably periventricular echogenicity. LSV was correlated with higher z-scores for head circumference and body length. LSV was not associated with congenital CMV.
CONCLUSIONS: This study indicated a relationship between LSV and increased head circumference and body length. Further research is warranted to explore LSV's pathophysiological mechanisms.