Bulletin de la Societe des sciences medicales du Grand-Duche de Luxembourg · 1989
Monitoring and treatment of minimal residual cancer of the prostate.
Duplicate PublicationСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Mathé G, Schally A V, Comaru-Schally A M, Mauvernay R Y, Vovan M L, Machover D, Misset J L, Court B, Bouchard P, Duchier J
Аннотация
In manifest prostatic carcinoma, partial and complete remissions are obtained in 14-44% of patients as judged by different sets of criteria, but in up to 61% as judged by a decrease in prostatic acid phosphatase. Moreover, this decrease is poorly correlated to that of prostatic size. Prostatic acid phosphatase is therefore considered to be a relatively non-specific tumor marker. A complete remission, i.e. a stage of minimal residual disease, is obtained in about 25% of the patients. Continued endocrine treatment involves the risk of a flare-up of the disease, which is probably small. Additionally, in minimal residual disease, prolonged maintenance treatment requires minimization of side effects. D-Trp-6-LH-RH appears to lead to less gynecomastia and thromboembolism than some other forms of adjuvant therapy.