BMC medical genetics · 2017
Gender differences in the prevalence of congenital heart disease in Down's syndrome: a brief meta-analysis.
СтатьяМетаанализСистематический обзорНазвание и аннотация: Перевод в очереди
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Diogenes Tereza Cristina Pinheiro, Mourato Felipe Alves, de Lima Filho José Luiz, Mattos Sandra da Silva
Аннотация
BACKGROUND: Down's syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40-60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them.
METHODS: We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included.
RESULTS: Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD.
CONCLUSION: CHD, particularly AVSD, are more common in the female gender of Down's syndrome patients.
METHODS: We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included.
RESULTS: Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD.
CONCLUSION: CHD, particularly AVSD, are more common in the female gender of Down's syndrome patients.