Schizophrenic syndromes associated with treatment response.

1. The influence of clinical syndromes (determined by factor analysis) on treatment response was explored in a sample of schizophrenics treated by clinician choice. Patients were obtained from 115 consecutive admissions to an acute inpatient unit and were diagnosed by DSM-III-R criteria. Patients were thoroughly assessed during the first five days of hospitalization using SANS-SAPS, TLC and SEB. Factor analyses of these scales were carried out to explore the existence of syndromes made up of groups of symptoms. All patients were treated with neuroleptics and 70% with biperiden (to exclude akinesia). The response to treatment was measured by the CGI efficacy index. 2. Inappropriate affect, asociality, negative formal thought disturbances and bizarre behavior syndromes showed significant correlation with poor response to treatment. Affective flattening did not display consistent significant correlations with the response to treatment. Visual hallucinations (an infrequent syndrome) and manic thought disorder (a non-specific syndrome) showed significant correlations with better response to neuroleptics. 3. In a stepwise multiple regression model to predict treatment response, asociality and inappropriate affect were the most important predictors. In a discriminant analysis dividing patients between responders and non-responders, the syndromes predicting poor response were more important that those predicting good response.