Journal of voice : official journal of the Voice Foundation · 2026
Immunohistochemical Expression of p16 and Its Association with Recurrence in Adult-Onset Recurrent Respiratory Papillomatosis: A Preliminary Study.
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Hasegawa Hisashi, Matsuzaki Hiroumi, Ouchi Toshitaka, Makiyama Kiyoshi, Tang Xiaoyan, Oshima Takeshi
Аннотация
BACKGROUND: Recurrent respiratory papillomatosis (RRP) is a rare, benign epithelial tumor primarily caused by low-risk human papillomavirus (HPV) types 6 and 11. Although p16 is widely used as a surrogate marker of high-risk HPV infections in other HPV-related malignancies, its role in RRP remains unclear.
OBJECTIVE: This study aimed to investigate the immunohistochemical expression of p16 in Adult-Onset RRP (AORRP) patients with RRP and evaluate its association with clinical recurrence.
METHODS: We retrospectively reviewed 64 adult patients primarily with AORRP who underwent surgical treatment for RRP at the Nihon University Hospital between January 2008 and March 2022. p16 expression was assessed using a standardized scoring system based on the staining intensity and proportion of positive cells. The patients were categorized into four groups: negative, low, intermediate, and high expression. Recurrence was defined as the need for additional surgical intervention after the initial treatment. Statistical analyses were performed using the Chi-square test.
RESULTS: p16 positivity (score ≥1) was observed in 51 (51/64:80%) cases. The high expression group (Score 5-6) demonstrated significantly higher recurrence rates than the negative group (P = 0.0036). All the patients in the high-expression group experienced recurrence. However, no significant difference was observed in the recurrence among the other groups.
CONCLUSION: High p16 expression may serve as a potential prognostic marker for AORRP recurrence. Given the simplicity and accessibility of immunohistochemical staining, p16 scoring may be considered a valuable tool for the risk stratification and long-term disease management of AORRP.
OBJECTIVE: This study aimed to investigate the immunohistochemical expression of p16 in Adult-Onset RRP (AORRP) patients with RRP and evaluate its association with clinical recurrence.
METHODS: We retrospectively reviewed 64 adult patients primarily with AORRP who underwent surgical treatment for RRP at the Nihon University Hospital between January 2008 and March 2022. p16 expression was assessed using a standardized scoring system based on the staining intensity and proportion of positive cells. The patients were categorized into four groups: negative, low, intermediate, and high expression. Recurrence was defined as the need for additional surgical intervention after the initial treatment. Statistical analyses were performed using the Chi-square test.
RESULTS: p16 positivity (score ≥1) was observed in 51 (51/64:80%) cases. The high expression group (Score 5-6) demonstrated significantly higher recurrence rates than the negative group (P = 0.0036). All the patients in the high-expression group experienced recurrence. However, no significant difference was observed in the recurrence among the other groups.
CONCLUSION: High p16 expression may serve as a potential prognostic marker for AORRP recurrence. Given the simplicity and accessibility of immunohistochemical staining, p16 scoring may be considered a valuable tool for the risk stratification and long-term disease management of AORRP.