Science (New York, N.Y.) · 2021
Debaryomyces is enriched in Crohn's disease intestinal tissue and impairs healing in mice.
СтатьяПоддержка NIH: внешняя программаПоддержка правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Jain Umang, Ver Heul Aaron M, Xiong Shanshan, Gregory Martin H, Demers Elora G, Kern Justin T, Lai Chin-Wen, Muegge Brian D, Barisas Derek A G, Leal-Ekman J Steven, Deepak Parakkal, Ciorba Matthew A, Liu Ta-Chiang, Hogan Deborah A, Debbas Philip, Braun Jonathan, McGovern Dermot P B, Underhill David M, Stappenbeck Thaddeus S
Аннотация
Alterations of the mycobiota composition associated with Crohn's disease (CD) are challenging to link to defining elements of pathophysiology, such as poor injury repair. Using culture-dependent and -independent methods, we discovered that Debaryomyces hansenii preferentially localized to and was abundant within incompletely healed intestinal wounds of mice and inflamed mucosal tissues of CD human subjects. D. hansenii cultures from injured mice and inflamed CD tissues impaired colonic healing when introduced into injured conventionally raised or gnotobiotic mice. We reisolated D. hansenii from injured areas of these mice, fulfilling Koch's postulates. Mechanistically, D. hansenii impaired mucosal healing through the myeloid cell-specific type 1 interferon-CCL5 axis. Taken together, we have identified a fungus that inhabits inflamed CD tissue and can lead to dysregulated mucosal healing.