Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 1988
Teratogenicity study of ammonium glycyrrhizinate in the Sprague-Dawley rat.
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Mantovani A, Ricciardi C, Stazi A V, Macri C, Piccioni A, Badellino E, De Vincenzi M, Caiola S, Patriarca M
Аннотация
Ammonium glycyrrhizinate (AG), a commercially used salt of glycyrrhizic acid, was administered in the drinking-water to Sprague-Dawley rats on days 7-17 of pregnancy. The actual intakes were 0, 21.33 +/- 1.22, 238.75 +/- 17.50 and 679.94 +/- 69.87 mg AG/kg body weight/day for groups 0, 1, 2 and 3, respectively. AG caused polydipsia in the dams. Foetuses from the treated litters did not present an increase in external malformations, a decrease in weight or a decrease in the degree of ossification. However, there was a slight but significant increase in embryolethality and in the prevalence of external haemorrhages. Skeletal examination revealed a dose-related increase in minor anomalies, especially in the sternebral variants. Renal ectopy also increased significantly at the highest dose. These results indicate that the possible embryotoxicity of aromatizing compounds should be considered.