AIDS research and human retroviruses · 2005
Molecular characteristics of HIV type 1 circulating in São Paulo, Brazil.
СтатьяНазвание и аннотация: Перевод в очереди
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Brígido Luis F M, Franco Heitor M, Custódio Renata M, Oliveira Carmen A F, P Ferreira João Leandro, Eira Margareth, Bergel Fernando, Araújo Fabio, Carvalheiro Jose R, Rodrigues Rosangela
Аннотация
Partial sequences of HIV-1 polymerase from 185 patients, 141 ARV experienced and 44 naive, of gag (p24) and env (C2V3) from a subset of naive cases were evaluated in São Paulo, Brazil. Antiretroviral resistance mutations were detected in 4% of 26 recently (<2 years) infected patients. Polymorphisms at the protease gene were common both in contemporary and pre-HAART era isolates, some significantly associated with the viral clade. HIV-1 clade B was preponderant, in 79%, with 11% clade F and one case of HIV-1 C. Recently infected women had a significantly higher proportion of non-B clade HIV-1. A mosaic pol was observed in 9%, all B/F except for one G mosaic. A CRF-12-BF structure, observed in 20% of B/F pol mosaics, provides evidence for an epidemic relationship in the major South American metropolitan areas.