Pattern of gonadotrophin secretion in patients with hyperandrogenaemic amenorrhoea before and after ovarian wedge resection.

The follow-up of androgen and gonadotrophin concentrations after ovarian wedge resection is reported in two patients with hyperandrogenaemic amenorrhoea. Elevated testosterone concentrations decreased immediately and androstenedione after 3 months. In a patient with polycystic ovarian disease, luteinizing hormone (LH) amplitudes were reduced in the presence of unchanged pulse frequency. Small decreases in mean LH baseline values were accompanied by increases in follicle stimulating hormone concentrations. Our data provide evidence that reduction of elevated ovarian androgen concentrations leads (directly or indirectly) to a decrease of exaggerated LH pulse amplitude in patients with hyperandrogenaemic amenorrhoea.