Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2009
Fetal cerebral ventricular pointing as a marker of spina bifida: incidence and observational agreement.
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Wax Joseph R, Pinette Michael G, Cartin Angelina, Michaud Janet, Blackstone Jacquelyn
Аннотация
OBJECTIVE: Occipital cerebral ventricular pointing is a promising intracranial marker for spina bifida. We sought to determine (1) the incidence of pointing in fetuses with and without spina bifida and (2) inter-observer and intraobserver agreement for visualizing pointing.
METHODS: Second-trimester transverse axial images of the lateral cerebral ventricles from an equal number of affected and unaffected fetuses were independently reviewed in a blinded fashion by 2 examiners.
RESULTS: Sixty-two fetuses (31 with isolated spina bifida and 31 without) had sonographic examinations at 19.2+/-1.3 weeks (mean+/-SD). Pointing was present in 77.3% of fetuses with spina bifida and 15% of those without by the first examiner and in 78.3% of fetuses with spina bifida and 10% of those without by the second examiner. Interobserver and intraobserver agreement were substantial (kappa=0.69 and 0.78, respectively).
CONCLUSIONS: Ventricular pointing is a highly agreed-on finding that is substantially associated with but not pathognomonic for fetal spina bifida.
METHODS: Second-trimester transverse axial images of the lateral cerebral ventricles from an equal number of affected and unaffected fetuses were independently reviewed in a blinded fashion by 2 examiners.
RESULTS: Sixty-two fetuses (31 with isolated spina bifida and 31 without) had sonographic examinations at 19.2+/-1.3 weeks (mean+/-SD). Pointing was present in 77.3% of fetuses with spina bifida and 15% of those without by the first examiner and in 78.3% of fetuses with spina bifida and 10% of those without by the second examiner. Interobserver and intraobserver agreement were substantial (kappa=0.69 and 0.78, respectively).
CONCLUSIONS: Ventricular pointing is a highly agreed-on finding that is substantially associated with but not pathognomonic for fetal spina bifida.