Translational neuroscience · 2023
Comprehensive behavioral study of C57BL/6.KOR-ApoEshl mice.
СтатьяНазвание и аннотация: Перевод в очереди
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Ueno Hiroshi, Takahashi Yu, Murakami Shinji, Wani Kenta, Miyazaki Tetsuji, Matsumoto Yosuke, Okamoto Motoi, Ishihara Takeshi
Аннотация
BACKGROUND: Apolipoprotein E (ApoE) is associated with Alzheimer's disease (AD) and cognitive dysfunction in elderly individuals. There have been extensive studies on behavioral abnormalities in ApoE-deficient (Apoeshl) mice, which have been described as AD mouse models. Spontaneously hyperlipidemic mice were discovered in 1999 as ApoE-deficient mice due to ApoE gene mutations. However, behavioral abnormalities in commercially available Apoeshl mice remain unclear. Accordingly, we aimed to investigate the behavioral abnormalities of Apoeshl mice.
RESULTS: Apoeshl mice showed decreased motor skill learning and increased anxiety-like behavior toward heights. Apoeshl mice did not show abnormal behavior in the Y-maze test, open-field test, light/dark transition test, and passive avoidance test.
CONCLUSION: Our findings suggest the utility of Apoeshl mice in investigating the function of ApoE in the central nervous system.
RESULTS: Apoeshl mice showed decreased motor skill learning and increased anxiety-like behavior toward heights. Apoeshl mice did not show abnormal behavior in the Y-maze test, open-field test, light/dark transition test, and passive avoidance test.
CONCLUSION: Our findings suggest the utility of Apoeshl mice in investigating the function of ApoE in the central nervous system.