Journal of global antimicrobial resistance · 2019
Multidrug-resistant CTX-M-15-positive Klebsiella pneumoniae ST307 causing urinary tract infection in a dog in Brazil.
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Sartori Luciana, Sellera Fábio P, Moura Quézia, Cardoso Brenda, Cerdeira Louise, Lincopan Nilton
Аннотация
OBJECTIVES: Klebsiella pneumoniae sequence type 307 (ST307) has emerged as a new high-risk clone worldwide. The aim of this study was to report the draft genome sequence of a multidrug-resistant CTX-M-15-positive K. pneumoniae strain causing urinary tract infection in a companion animal in Brazil.
METHODS: Whole-genome sequencing was performed on an Illumina NextSeq platform and the genome was de novo assembled using SPAdes. Data analysis was performed using online tools from the Center for Genomic Epidemiology.
RESULTS: The genome size of K. pneumoniae strain PRETA was calculated at 5 450 575 bp, containing a total of 5355 protein-coding sequences. The strain was assigned to the high-risk ST307 and carried the clinically relevant blaCTX-M-15 gene, besides other genes conferring resistance to aminoglycosides, tetracyclines, quinolones, trimethoprim and fosfomycin.
CONCLUSION: These data offer novel information for comparative genomic analyses in order to track the transmission dynamics and epidemiology of the newly emerging high-risk clone ST307.
METHODS: Whole-genome sequencing was performed on an Illumina NextSeq platform and the genome was de novo assembled using SPAdes. Data analysis was performed using online tools from the Center for Genomic Epidemiology.
RESULTS: The genome size of K. pneumoniae strain PRETA was calculated at 5 450 575 bp, containing a total of 5355 protein-coding sequences. The strain was assigned to the high-risk ST307 and carried the clinically relevant blaCTX-M-15 gene, besides other genes conferring resistance to aminoglycosides, tetracyclines, quinolones, trimethoprim and fosfomycin.
CONCLUSION: These data offer novel information for comparative genomic analyses in order to track the transmission dynamics and epidemiology of the newly emerging high-risk clone ST307.
Предметные рубрики MeSH
AnimalsAnti-Bacterial AgentsBacterial ProteinsBase SequenceBrazilDog DiseasesDogsDrug Resistance, Multiple, BacterialGenome SizeGenome, BacterialKlebsiella InfectionsKlebsiella pneumoniaeMicrobial Sensitivity TestsMultilocus Sequence TypingUrinary Tract InfectionsVirulence FactorsWhole Genome Sequencingbeta-Lactamases