Nature communications · 2024
Divergent evolution of male-determining loci on proto-Y chromosomes of the housefly.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Li Xuan, Visser Sander, Son Jae Hak, Geuverink Elzemiek, Kıvanç Ece Naz, Wu Yanli, Schmeing Stephan, Pippel Martin, Anvar Seyed Yahya, Schenkel Martijn A, Marec František, Robinson Mark D, Meisel Richard P, Wimmer Ernst A, van de Zande Louis, Bopp Daniel, Beukeboom Leo W
Аннотация
Houseflies provide a good experimental model to study the initial evolutionary stages of a primary sex-determining locus because they possess different recently evolved proto-Y chromosomes that contain male-determining loci (M) with the same male-determining gene, Mdmd. We investigate M-loci genomically and cytogenetically revealing distinct molecular architectures among M-loci. M on chromosome V (MV) has two intact Mdmd copies in a palindrome. M on chromosome III (MIII) has tandem duplications containing 88 Mdmd copies (only one intact) and various repeats, including repeats that are XY-prevalent. M on chromosome II (MII) and the Y (MY) share MIII-like architecture, but with fewer repeats. MY additionally shares MV-specific sequence arrangements. Based on these data and karyograms using two probes, one derives from MIII and one Mdmd-specific, we infer evolutionary histories of polymorphic M-loci, which have arisen from unique translocations of Mdmd, embedded in larger DNA fragments, and diverged independently into regions of varying complexity.