Crystal structure and Hirshfeld surface analysis of [(R,S)-2,8-bis-(tri-fluoro-meth-yl)quinolin-4-yl](piperidin-2-yl)methanol methanol monosolvate.

The title compound, C17H16F6N2O·CH3OH, is composed of a quinolinyl group and a piperidinyl group connected via a hy-droxy-methine (-CHOH) functionality. The compound, which is monosolvated by methanol, was crystallized via slow evaporation of a methanol solution, yielding colorless prism-like crystals. The hy-droxy-methine center of the compound is in the absolute R configuration, whereas the chiral center of the piperidinyl ring is in the S configuration. The conformation of the piperidinyl ring is a chair. The supra-mol-ecular architecture of the crystal is sustained by a set of hydrogen bonds: O-H⋯O, N-H⋯O and C-H⋯F. The inter-molecular forces are further analyzed and confirmed by a Hirshfeld surface analysis. DFT structural data computed with the ORCA quantum chemistry program package using the B3LYP/def2-TZVPP basis set compare quite well with the experimental X-ray crystal structural data.