[Changes in fibrinogen, fibrin-fibrinogen degradation products and fibrinolytic activity during pregnancy, labor and the puerperium in pregnant women with chronic hypertension].

In this study 79 pregnant women were analyzed, during the pregnancy, delivery and postnatal period. The control group consisted of 41 healthy women, while in the studied group there were 38 patients with severe chronic hypertension. Analyzed parameters: fibrinogen, fibrinolysis and FDP. Parameters were performed in all cases of pregnancies during third trimester (I), during the first stage of labor (II), immediately after delivery of placenta (III), two hours after placenta was delivered (IV), eight hours (V), 24 hours (VI), 48 hours (VII) and 72 hours (VIII) after placenta was delivered. Comparing certain measures in fibrinogen's value, high statistical significance was obtained for control group (healthy women), ANOVA (F = 5.17; p < 0.001) and for studied group (women for chronic hypertension), (F = 3.17; p < 0.001. Analyses of FDP values showed high statistically significant difference for control group, F = 15.03; p < 0.00001, and for studied group, F = 10.56; p < 0.00001. Statistically significant difference in fibrinolytic activity was obtained for control group, F = 60.72; p < 0.0001 and studied group, F = 5.70; p < 0.0001.