International medical case reports journal · 2021
IgA Deficiency and Membranoproliferative Glomerulonephritis: A Case Report.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Pezzutto Alessandro, Sirolli Vittorio, Di Liberato Lorenzo, Morroni Manrico, Bonomini Mario
Аннотация
BACKGROUND: Immunoglobulin A deficiency (IgAD) is the most common form of primary immunodeficiency in western countries. It can be associated with the development of autoimmune diseases both in adults and in children even though the exact pathophysiology is not fully defined.
CASE PRESENTATION: We report here a case of a young patient who developed nephrotic syndrome secondary to membranoproliferative glomerulonephritis associated with the incidental finding of IgAD. We began corticosteroid therapy and angiotensin-converting enzyme inhibitor, and we observed partial remission of the nephrotic syndrome after about nine months; nonetheless, in the following follow-up visits, a progressive decline of renal function was found.
CONCLUSION: Our case extends the spectrum of hitherto described glomerulonephritides associated with IgAD which were described until now.
CASE PRESENTATION: We report here a case of a young patient who developed nephrotic syndrome secondary to membranoproliferative glomerulonephritis associated with the incidental finding of IgAD. We began corticosteroid therapy and angiotensin-converting enzyme inhibitor, and we observed partial remission of the nephrotic syndrome after about nine months; nonetheless, in the following follow-up visits, a progressive decline of renal function was found.
CONCLUSION: Our case extends the spectrum of hitherto described glomerulonephritides associated with IgAD which were described until now.