Internal medicine (Tokyo, Japan) · 2020
IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Kawabata Hideaki, Kawakatsu Yukino, Inoue Naonori, Okazaki Yuji, Sone Daiki, Yamaguchi Katsutoshi, Ueda Yuki, Hitomi Misuzu, Miyata Masatoshi, Motoi Shigehiro, Enoki Yasuyuki, Minamikawa Tetsuhiro
Аннотация
A 69-year-old man was referred to our department with acute hepatitis. He had been newly treated with benidipine hydrochloride for two months. His blood test results were as follows: aspartate aminotransferase, 1,614 IU/L; alanine aminotransferase, 1,091 IU/L and anti-smooth muscle antibody, ×80. Needle liver biopsy specimen showed interface hepatitis with mainly lymphocytic infiltration and bridging fibrosis in the periportal area. Immunohistochemistry revealed lymphocytic infiltration positive for IgG4. We diagnosed him with IgG4-related AIH with an etiology that was suspected of being drug-induced. Oral prednisolone was started and then tapered after achieving biochemical remission. Hepatitis recurred after the cessation of steroids; however, remission was achieved with ursodeoxycholic acid.