[Distribution, diffuse, and removal of tetracyclines and sulfonamide antibiotic resistance genes in wastewater treatment plant: A review.].

The contamination of antibiotic resistance genes (ARGs) caused by abuse of antibiotics has attracted more and more attention. Due to their low price, tetracyclines and sulfonamides are widely used. The plenty of residual tetracyclines and sulfonamides is discharged into wastewater treatment plant (WWTPs), with consequent ARGs pollution. To understand the current status of ARGs contamination and removal efficiency, we summarized the distribution and spread mechanism of tetracyclines and sulfonamides ARGs, and further emphasized the ARGs removal efficiency across different treatment technologies. Based on the current knowledge and lack of ARGs, future work were proposed, such as investigating ARGs contamination in WWTPs, improving ARGs removal technologies, exploring spread mechanisms of ARGs.