Enhancing Biochemistry Education Through Movement-Based Learning: Investigating Oxygen Delivery Using Personal Health Data.

Students in undergraduate biochemistry courses often struggle to connect molecular mechanisms with dynamic physiological processes. To bridge these ideas, a novel laboratory module titled Cardio Chemistry: The Human Element was implemented to investigate oxygen delivery through the use of real-time personal health data. Using wearable fitness trackers and metabolic monitoring, students collected individual data on oxygen saturation, oxygen uptake, carbon dioxide production, and respiratory exchange ratio during a guided aerobic fitness assessment. Designed as a mixed-methods, within-subject case study, the intervention was evaluated through pre/postlab assessments, exam scores, reflective responses, and surveys. Students who completed the activity demonstrated significant gains in conceptual understanding, with postlab Bohr effect comprehension reaching 100% alongside significantly higher final exam scores compared to nonparticipants (p < 0.05). Self-reported familiarity with physiological metrics increased across all variables (p < 0.001), and reflections indicated enhanced engagement and relevance. These findings suggest that integrating physiological data into biochemistry instruction improves mechanistic understanding, fosters interdisciplinary thinking, and supports knowledge transfer to clinical and real-world contexts.