Controversy and Consensus on Indications for Sperm DNA Fragmentation Testing in Male Infertility: A Global Survey, Current Guidelines, and Expert Recommendations.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Agarwal Ashok, Farkouh Ala'a, Saleh Ramadan, Abdel-Meguid Hamoda Taha Abo-Almagd, Harraz Ahmed M, Kavoussi Parviz, Arafa Mohamed, Salvio Gianmaria, Rambhatla Amarnath, Toprak Tuncay, Gül Murat, Phuoc Nguyen Ho Vinh, Boitrelle Florence, Birowo Ponco, Ghayda Ramy Abou, Cannarella Rossella, Kuroda Shinnosuke, Durairajanayagam Damayanthi, Zini Armand, Wyns Christine, Sarikaya Selcuk, Tremellen Kelton, Mostafa Taymour, Sokolakis Ioannis, Evenson Donald P, Henkel Ralf, Zohdy Wael, Chung Eric, Ziouziou Imad, Falcone Marco, Russo Giorgio I, Al-Hashimi Manaf, Calogero Aldo E, Ko Edmund, Colpi Giovanni, Lewis Sheena, Serefoglu Ege Can, Bahar Fahmi, Martinez Marlon, Nguyen Quang, Ambar Rafael F, Bakircioglu Mustafa Emre, Kandil Hussein, Mogharabian Nasser, Sabbaghian Marjan, Taniguchi Hisanori, Tsujimura Akira, Sajadi Hesamoddin, Ibrahim Wael, Atmoko Widi, Vogiatzi Paraskevi, Gunes Sezgin, Sadighi Gilani Mohammad Ali, Roychoudhury Shubhadeep, Güngör Nur Dokuzeylül, Hakim Lukman, Adriansjah Ricky, Kothari Priyank, Jindal Sunil, Amar Edouard, Park Hyun Jun, Long Tran Quang Tien, Homa Sheryl, Karthikeyan Vilvapathy Senguttuvan, Zilaitiene Birute, Maldonado Rosas Israel, Marino Angelo, Pescatori Edoardo, Ozer Cevahir, Akhavizadegan Hamed, Garrido Nicolas, Busetto Gian Maria, Adamyan Aram, Al-Marhoon Mohamed, Elbardisi Haitham, Dolati Parisa, Darbandi Mahsa, Darbandi Sara, Balercia Giancarlo, Pinggera Germar-Michael, Micic Sava, Ho Christopher Chee Kong, Moussa Mohamad, Preto Mirko, Zenoaga-Barbăroșie Cătălina, Smith Ryan P, Kosgi Raghavender, de la Rosette Jean, El-Sakka Ahmed I, Abumelha Saad Mohammed, Mierzwa Tiago Cesar, Ong Teng Aik, Banihani Saleem A, Bowa Kasonde, Fukuhara Shinichiro, Boeri Luca, Danacıoğlu Yavuz Onur, Gokalp Fatih, Selim Osama Mohamed, Cho Chak-Lam, Tadros Nicholas N, Ugur Muhammet Rasit, Ozkent Mehmet Serkan, Chiu Peter, Kalkanli Arif, Khalafalla Kareim, Vishwakarma Ranjit B, Finocchi Federica, Andreadakis Sotiris, Giulioni Carlo, Çeker Gökhan, Ceyhan Erman, Malhotra Vineet, Yilmaz Mehmet, Timpano Massimiliano, Barrett Trenton L, Kim Shannon Hee Kyung, Ahn Sun-Tae, Giacone Filippo, Palani Ayad, Duarsa Gede Wirya Kusuma, Kadioglu Ates, Gadda Franco, Zylbersztejn Daniel Suslik, Aydos Kaan, Kulaksız Deniz, Gupte Deepak, Calik Gokhan, Karna Keshab Kumar, Drakopoulos Panagiotis, Baser Aykut, Kumar Vijay, Molina Juan Manuel Corral, Rajmil Osvaldo, Ferreira Raphael H, Leonardi Sofia, Avoyan Armen, Sogutdelen Emrullah, Franco Giorgio, Ramsay Jonathan, Ramirez Liliana, Shah Rupin, Global Andrology Forum
Аннотация
MATERIALS AND METHODS: Clinicians managing male infertility were invited to take part in a global online survey on SDF clinical practices. This was conducted following the CHERRIES checklist criteria. The responses were compared to professional society guideline recommendations related to SDF and the appropriate available evidence. Expert recommendations on indications for SDF testing were then formulated, and the Delphi method was used to reach consensus.
RESULTS: The survey was completed by 436 experts from 55 countries. Almost 75% of respondents test for SDF in all or some men with unexplained or idiopathic infertility, 39% order it routinely in the work-up of recurrent pregnancy loss (RPL), and 62.2% investigate SDF in smokers. While 47% of reproductive urologists test SDF to support the decision for varicocele repair surgery when conventional semen parameters are normal, significantly fewer general urologists (23%; p=0.008) do the same. Nearly 70% would assess SDF before assisted reproductive technologies (ART), either always or for certain conditions. Recurrent ART failure is a common indication for SDF testing. Very few society recommendations were found regarding SDF testing.
CONCLUSIONS: This article presents the largest global survey on the indications for SDF testing in infertile men, and demonstrates diverse practices. Furthermore, it highlights the paucity of professional society guideline recommendations. Expert recommendations are proposed to help guide clinicians.